Manufacturer Direct-to-Employer Pharmacy Benefit Infrastructure
ApalyRx provides the complete operational, regulatory, and technology infrastructure that makes a manufacturer's direct-to-employer channel executable.
The Direct-to-Employer Channel Is Taking Shape Now
Employer-sponsored health plans cover 154 million Americans. Self-funded employers, who represent 67% of that market, have the legal authority under ERISA to design their own pharmacy benefit and access manufacturer-direct pricing without PBM formulary permission. Manufacturers who establish credible, compliant direct-to-employer infrastructure now will help define the standard.
The legislative environment has shifted materially. Regulatory scrutiny of intermediary practices is at its highest point in a generation. The manufacturers who move now will be significantly better positioned than those who wait.
ApalyRx has built the infrastructure. The question is not whether to build a direct-to-employer channel. It is whether your organization accesses what is already operational today.
of WAC captured by intermediaries in standard distribution. Wholesaler margin, PBM spread, specialty pharmacy fees, and rebate float.
rebates held by intermediaries before any portion reaches the employer plan
Americans in self-funded employer plans. A channel that does not require formulary permission to access.
Infrastructure Built for Two Parties.
Designed for One Outcome.
Your DTE Channel. Ready to Activate.
ApalyRx provides the complete operating layer for manufacturer direct-to-employer programs: eRx intake, eligibility, fulfillment routing, medical-claim billing, accumulator reporting, and supplier settlement. Your existing channel arrangements remain intact by architecture, not by workaround.
Manufacturer Infrastructure →Lowest Net Cost. Every Script. Full Audit Record.
Configure targeted drug programs, access manufacturer-direct pricing inside your benefit, and receive decision-level documentation for every fulfillment decision. Works alongside your existing PBM and TPA. Nothing changes except the cost and the transparency.
Employer Platform →One Platform. Every Party. Every Prescription.
Configure
Manufacturers load products and program pricing. Employers define drug scope, cost-share rules, and eligibility. The platform is ready to receive prescriptions through the standard e-prescribing workflow. Nothing changes for prescribers.
Route
Every in-scope prescription is evaluated across all plan-activated supply channels in real time. The platform applies program rules and routes to the most appropriate channel for that specific prescription. This is the first time routing has existed in pharmacy benefits. Until now, prescriptions were simply fulfilled through a predetermined channel.
Dispense
The prescription routes to the member’s local pharmacy. The drug ships directly to that pharmacy. The pharmacist conducts clinical review and dispenses to the member.
Settle
ApalyRx bills the plan, collects member cost-share, and pays the dispensing pharmacy, all simultaneously at the point of dispense. Every prescription generates a decision-level record. Every party is paid. Every decision is documented.
Built for Enterprise Scale and Compliance
ApalyRx is the only platform that meets all five Drug Benefit Integrity requirements simultaneously. Real-time routing, no channel ownership, manufacturer-direct programs inside the benefit, independent pharmacy fulfillment, and per-prescription decision-level records.
Existing Arrangements Protected by Architecture
The manufacturer's only counterparty is ApalyRx. There are no direct employer relationships to establish or defend. Existing channel relationships with necessary partners are preserved by design through a commercial structure built around a single contracted relationship, one counterparty, one monthly invoice, one rebate line deduction.
Full DSCSA Compliance in a Custody-Without-Title Model
The only platform that generates per-prescription DSCSA T3 documentation in a custody-without-title 3PL model without a standard change-of-ownership trigger. No existing compliance tool, distributor, or specialty pharmacy has solved this. No manufacturer system builds required.
One Ship-To Address. ApalyRx Handles Everything Else.
The manufacturer ships bulk to the ApalyRx-designated 3PL on its existing monthly cadence, identical to any distributor shipment. ApalyRx manages 3PL coordination, pharmacy credentialing across all 50 states, DSCSA documentation, fulfillment routing, and all downstream operations.
This Is Not a Pilot Program. The Infrastructure Is Operational Today.
ApalyRx has been operating since 2018 and serves Fortune 500 employers. The platform is live, compliant, and ready to activate. Tell us which high-cost drugs are driving your costs. We will show you how ApalyRx addresses them.
Drug Benefit Integrity
The only platform meeting all five requirements simultaneously.
Transparency tells you what happened. Drug Benefit Integrity proves the decision was sound. ApalyRx is the only platform that meets all five structural requirements for ensuring pharmacy benefit decisions are made in the plan's interest.